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KMID : 1161420160190090844
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Journal of Medicinal Food
2016 Volume.19 No. 9 p.844 ~ p.852
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Evaluation of the Antihyperglycemic Effect of Minor Steviol Glycosides in Normoglycemic and Induced-Diabetic Wistar Rats
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Aranda-Gonzalez Irma
Moguel-Ordonez Yolanda
Chel-Guerrero Luis
Segura-Campos Maira
Betancur-Ancona David
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Abstract
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Steviol glycosides are a family of compounds found in Stevia rebaudiana Bertoni that are responsible for sweetness capacity. The antihyperglycemic effect of the two major steviol glycosides, Rebaudioside A and Stevioside, has been studied and it has been found that despite having the same common structure, only Stevioside exerts an antihyperglycemic effect. Although other steviol derivatives are found in smaller amounts (minor steviol glycosides) in S. rebaudiana, whether or not they possess antihyperglycemic activity has not been evaluated. The aim of this study was to evaluate the antihyperglycemic effect of minor steviol glycosides in normoglycemic and diabetic (streptozotocin/nicotinamide) Wistar rats. Rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) both before and after chronic treatment (28 days). After 6?h of fasting, IPGTT was conducted in pentobarbital-anesthetized rats using 1?g/kg of glucose plus 20?mg/kg of the minor glycoside (Dulcoside A, Rebaudioside B, C, D, or Steviolbioside) or control treatment (distilled water, glibenclamide, or metformin); the blood of the tip of the tail was collected at time 0, 15, 30, 60, and 120?min.; and blood glucose was measured, and its net area under the curve (AUCnet) was calculated. After 28-day chronic oral administration, IPGTT was again performed. Differences were considered significant at P?
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KEYWORD
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antihyperglycemic, dulcoside, rebaudioside, Stevia rebaudiana, steviol glycosides, steviolbioside
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